In 2029, the Mutant population has shrunk significantly and the X-Men have disbanded. No new mutants have been born in over twenty years, and as their numbers dwindled, Professor X’s dreams of a new stage in evolution slowly died.
A weary Logan has surrendered himself to alcoholism, now earns a living as a limo-driving chauffeur in a town on the Mexican border, and is hustling for medication that he takes out south to a remote, makeshift home and hideout, he shares with Caliban, nursemaid to the ailing and infirm, old Professor X, whom he and Caliban take care of and keep hidden away. In addition, Logan’s power to self-heal is dwindling; fading as he has aged, with his face and body being scarred from past injuries and battles.
One day, Logan’s attempts to hide from the world and his legacy are ended when a female stranger asks him to drive a girl named Laura to the Canadian border. At first, Logan refuses, but the Professor reveals that he has been waiting a long time for her to appear. Laura possesses an extraordinary fighting prowess and is in many ways like Wolverine. She is pursued by dark forces and sinister figures working for a powerful corporation because her DNA contains the secret that connects her to Logan. A relentless pursuit begins, and a decrepit Wolverine is forced to ask himself if he can or even wants to put his remaining powers to good use, as he he is drawn back into action, despite his hopelessness.